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In murine models of breast cancer, ICIE significantly transformed the TME from immunologically cold to hot by diminishing immunosuppressive cells (Tregs, M2-TAMs, MDSCs), augmenting the infiltration of CTLs, and elevating the CD 8+ /Treg ratio

and has been approved by the Food and Drug Administration (FDA) and European Medicines Agency (EMA) for the treatment of moderate to severe UC, which is the most widely used non-immunogenic oral small molecule drug in clinical practice [195]

First, the hyperacetylation of the mitochondrial malate-aspartate shuttle protein inhibits the oxidation and transport of NADH in the mitochondria, resulting in an imbalance of redox in the cytoplasm

Quercetin belongs to the family Quercaceae

Then, the filtered datasets were compared to the Omit LaccID condition, using a P -value cutoff of 0.01 and an FDR of 5% for monocultures and 10% for cocultures (Supplementary Table 2 and Supplementary Figs

338,339 High expression of miR-24-3p, miR-199a-3p and miR-29a-3p has been shown to improve the intestinal barrier in UC, thereby alleviating disease progression